|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We investigated the influence of the rs6656401 single nucleotide polymorphisms (SNP) of the CR1 gene, the rs3851179 SNP of the PICALM gene, and the rs11136000 SNP of the CLU gene on risk of AD in a Polish population.
|
23650005 |
2013 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We detected a significant association of the MTHFR rs1801133 and PICALM rs3851179 polymorphisms with AD.
|
25359311 |
2015 |
|
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
We also tested for epistatic interaction between these variants and APOE ε4 as well as with the previously replicated LOAD GWAS genes (CLU: rs11136000, CR1: rs3818361, and PICALM: rs3851179).
|
21321396 |
2011 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We failed to replicate this association between the rs3851179 polymorphism and AD in all samples and the APOEε4-negative subgroup.
|
23040034 |
2013 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Unadjusted, CLU (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.85-0.96 for single-nucleotide polymorphism [SNP] rs11136000), CR1 (OR, 1.14; 95% CI, 1.07-1.22; SNP rs3818361), and PICALM (OR, 0.89; 95% CI, 0.84-0.94, SNP rs3851179) were associated with AD in white individuals.
|
20697030 |
2010 |
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study demonstrates an association between PICALM rs3851179 and GDM as well as IGT.
|
28316001 |
2017 |
|
Gestational Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study demonstrates an association between PICALM rs3851179 and GDM as well as IGT.
|
28316001 |
2017 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86).
|
19734902 |
2009 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86).
|
19734902 |
2009 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86).
|
19734902 |
2009 |
|
Memory impairment
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was an effect of the APOE-PICALM (rs3851179) interactions on reduced CMRgl in regions of vDMN (P < .001), and on memory deficits (F<sub>3,93</sub> =5.568, P = .020).
|
29883038 |
2019 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
There was no association observed with AD at both rs11136000 CLU (p=0.25) and rs3851179 PICALM (p=0.54).
|
28558900 |
2017 |
|
Parkinson Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
The two other SNPs, rs6656401 from CR1, and rs3851179 from PICALM region were not associated with PD (p>0.05).
|
21912625 |
2011 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The sensitivity analysis indicates that the association between rs3851179 and AD did </span>not vary substantially.
|
27048444 |
2017 |
|
Mild cognitive disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
The PICALM rs3851179 polymorphism significantly affects the DMN network in MCI.
|
28549650 |
2017 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The PICALM rs3851179 A allele is thought to have a protective effect, whereas the G allele appears to confer risk for AD.
|
28073596 |
2017 |
|
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
The most significant single-nucleotide polymorphisms in CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179) were tested for allelic association with LOAD.
|
20554627 |
2010 |
|
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
The effects for all SNPs, except rs3851179, were consistent with those for LOAD risk.
|
24670887 |
2014 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The association between rs3851179 (PICALM), rs744373 (BIN1), and AD was further confirmed by meta-analysis of Asian populations.
|
25452228 |
2016 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The allele T of rs38</span>51179 in PICALM was associated with a 13 % increase in the risk of AD.
|
26611835 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT).
|
28316001 |
2017 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT).
|
28316001 |
2017 |
|
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms at the LOAD risk loci CLU (rs11136000), CR1 (rs6656401, rs3818361), and PICALM (rs3851179) were genotyped and tested for association with Logical Memory immediate recall, Logical Memory delayed recall, Logical Memory percent retention, Visual Reproduction immediate recall, Visual Reproduction delayed recall, and Visual Reproduction percent retention scores from the Wechsler Memory Scale-Revised using multivariable linear regression analysis, adjusting for age at exam, sex, education, and apolipoprotein E ε4 dosage.
|
23643458 |
2014 |
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Re: "PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer's Disease in an Asian Population".
|
26972434 |
2016 |
|
Schizophrenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms rs11136000 and rs3851179 were analyzed among 184 Chinese patients with schizophrenia and 162 healthy controls.
|
20738160 |
2010 |